Restylane – the newest non-surgical dermal filler for treatment of wrinkles in the facial area. Restylane works best on those wrinkles present with or without facial movement, although it is also useful for treatment with dynamic wrinkles on the face. Local anesthesia either topical or local injections is required. The expected length of improvement is between four and twelve months, depending on the location of treatment. No testing for allergic reaction is required, and Restylane is non-animal derived.